Under the strategy of competition among major powers, the US military continues to promote the development and construction of hypersonic defense systems from three aspects of sensor layer, command and control, and interception weapons. Finally, this can offset the equipment advantages of hypersonic weapons and crack the anti-intervention/regional denial capabilities of opponents in “competition among major powers”. Since the US Department of Defense decided to adopt a layered defense strategy for hypersonic defense, the US military has fully relied on the existing ballistic missile defense systems. By exploring emerging technologies, developing various interception methods, and cooperating with allies, the US military builds a multi-platform early warning and detection system based on space and supplemented by ground and sea sensors. Meanwhile, a networked command and control system with real-time transmission and sky-to-earth connectivity is established. An interception system that mainly involves gliding interception and terminal interception with multiple interception methods coexisting is planned to build the theater-level hypersonic defense capability by 2034.